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Adult Craniopharyngiomas

Adult Craniopharyngiomas PDF Author: Emmanuel Jouanneau
Publisher: Springer Nature
ISBN: 3030411761
Category : Medical
Languages : en
Pages : 231

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Book Description
This volume focuses on adult craniopharyngiomas, offering various perspectives. The first part of the book provides an up-to-date overview of the pathogenesis and management of adult craniopharyngiomas, helping readers understand the pathogenesis and molecular pathways. It highlights the importance of animal models for addressing molecular keys and for developing targeted therapies. The second part deals with clinical management, detailing the latest results in the era of endoscopic surgery, including the major contribution of the extended nasal endoscopic approaches for suprasellar and retrochiasmatic tumors. The book also discusses the key aspects of these tumors and how to manage them. The last part of the book addresses the future therapies and recurrences after surgery and radiotherapy. This volume is of interest to neurosurgeons, endocrinologists, paediatricians, radiologists and oncologists.

Adult Craniopharyngiomas

Adult Craniopharyngiomas PDF Author: Emmanuel Jouanneau
Publisher: Springer Nature
ISBN: 3030411761
Category : Medical
Languages : en
Pages : 231

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Book Description
This volume focuses on adult craniopharyngiomas, offering various perspectives. The first part of the book provides an up-to-date overview of the pathogenesis and management of adult craniopharyngiomas, helping readers understand the pathogenesis and molecular pathways. It highlights the importance of animal models for addressing molecular keys and for developing targeted therapies. The second part deals with clinical management, detailing the latest results in the era of endoscopic surgery, including the major contribution of the extended nasal endoscopic approaches for suprasellar and retrochiasmatic tumors. The book also discusses the key aspects of these tumors and how to manage them. The last part of the book addresses the future therapies and recurrences after surgery and radiotherapy. This volume is of interest to neurosurgeons, endocrinologists, paediatricians, radiologists and oncologists.

Craniopharyngioma – A childhood and adult disease with different characteristics

Craniopharyngioma – A childhood and adult disease with different characteristics PDF Author: Hermann L. Mueller
Publisher: Frontiers E-books
ISBN: 2889190617
Category :
Languages : en
Pages : 91

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Book Description
Craniopharyngiomas are benign, partly cystic embryogenic malformations of the sellar region, presumably derived from Rathke cleft epithelium. With an overall incidence of 0.5–2 new cases per million population per year, approximately 30-50% of all cases represent childhood craniopharyngioma. Typical manifestations at primary diagnosis are headache, visual impairment, polyuria/polydypsia, growth retardation, and weight gain. One of the biggest challenges in treating craniopharyngioma is identifying the best candidates for the radical versus the conservative approach. It appears there is a trend towards radiotherapy in centers with past prevalent surgical approaches, and towards more radical surgical treatment strategies in centers historically conservative-oriented. There are current prospective studies underway on a national and multinational level to adopt strategies tailored to risk factors for morbidity and QOL. Therapy of choice in patients with favorable tumor localization is total resection with the intention to maintain optical nerve and hypothalamic-pituitary functions. In patients with unfavorable tumor localization (hypothalamic tumor involvement), a limited resection followed by local irradiation is recommended. The overall survival rates are high (92%). Recurrences after complete resection and progressions of residual tumor after incomplete resection are anticipated subsequent events after primary surgery. In clinical practice, the timing of postoperative residual tumor irradiation is both unclear and inconsistently regarded. Some favor immediate postoperative irradiation in the event of life-impairing clinical conditions, proactively preventing tumor progression. On the other hand, some favor a wait-and-see procedure, delaying irradiation in order to reduce both its necessity and the negative consequences associated with radiation therapy. Inarguably, immediate postoperative irradiation significantly delays tumor progression. However, progression-contingent irradiation has proved effective, as overall survival is statistically unaffected by this wait-and-see strategy. Accordingly, the appropriate time point of irradiation after incomplete resection is currently under investigation in a randomized trial (KRANIOPHARYNGEOM 2007). Quality of life is substantially reduced in appr. 50% of long-term survivors due to sequelae, notably extreme obesity due to hypothalamic involvement. Due to the lack of satisfactory long-term treatment modalities for hypothalamic sequelae, further research on molecular characteristics of craniopharyngioma, pathophysiology of hypothalamic disorders, and pharmaceutical agents to treat hypothalamic obesity are warranted. Risk-adapted surgical strategies at initial diagnosis should aim at a maximal degree of resection, respecting the integrity of optical and hypothalamic structures in order to prevent severe sequelae and therein minimizing consequences that could negative impact patient QOL. Because initial hypothalamic tumor involvement has an apriori effect on the clinical course, childhood craniopharyngioma should be recognized as a chronic disease requiring constant monitoring of the consequences and medical resources for treatment in order to provide not only optimal QOL for patients, but also to garner additional information with the intent of minimizing what at present are severe consequences of both the disease and its treatment.

Craniopharyngiomas

Craniopharyngiomas PDF Author: James J. Evans
Publisher: Academic Press
ISBN: 0124167233
Category : Medical
Languages : en
Pages : 612

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Book Description
Craniopharyngiomas: A Comprehensive Guide to Diagnosis, Treatment and Outcome is a comprehensive guide to the science, diagnosis and treatment of craniopharyngiomas, rare brain tumors that grow near the pituitary gland. Even though these tumors are generally benign, due to the location, prognosis was often bleak. This reference provides a resource for specialists requiring a comprehensive overview of this rare form of tumor, outlining new diagnostic, imaging and surgical techniques, including endoscopic endonasal cranial base surgery, which enable successful neurosurgical intervention. With a better prognosis, patients require multidisciplinary management from neurology, otolaryngology, radiation oncology, endocrinology, and neuropathology. The only comprehensive guide to the science, diagnosis and treatment of craniopharyngiomas Includes multidisciplinary management from neurology, otolaryngology, radiation oncology, endocrinology, and neuropathology Detailed coverage of the impacts of new diagnostic, imaging and neurosurgical techniques including endoscopic endonasal cranial base surgery

Duke Radiology Case Review

Duke Radiology Case Review PDF Author: James M. Provenzale
Publisher: Lippincott Williams & Wilkins
ISBN: 9780397516131
Category : Medical
Languages : en
Pages : 616

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Book Description
This comprehensive and thoroughly illustrated radiology board review was prepared by the prestigious Duke University Department of Radiology. The book follows a case study format that challenges the reader to reach a diagnosis by presenting images, findings, and differential diagnosis before revealing the actual diagnosis.Three hundred cases are presented that cover every area of radiology, including chest imaging, breast imaging, neuroradiology, musculoskeletal imaging, vascular imaging, gastrointestinal imaging, genitourinary imaging, pediatric radiology, nuclear radiology, and ultrasound. Each case begins with a patient history, several images, and descriptions of the imaging findings, and then proceeds to a differential diagnosis and the actual diagnosis. The diagnosis is followed by a Key Facts section, divided into Clinical Facts and Radiologic Facts, that features bulleted common-sense pointers regarding pathologic and radiologic manifestations of the disease. Each case ends with a list of references.

Diagnosis and Management of Craniopharyngiomas

Diagnosis and Management of Craniopharyngiomas PDF Author: Andrea Lania
Publisher: Springer
ISBN: 331922297X
Category : Medical
Languages : en
Pages : 153

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Book Description
This book provides up-to-date coverage of the most relevant topics in the diagnosis and management of craniopharyngiomas. After introductory discussion of natural history and clinical presentation, individual chapters are devoted to pathological and molecular aspects, use of diagnostic imaging techniques, the surgical approach to craniopharyngiomas, radiotherapy and radiosurgery, and associated endocrine disturbances. A particular feature of the book is the detailed attention devoted to the metabolic consequences of the disease and related treatments, including obesity and electrolyte disturbances, and to cognitive alterations. This book will be of value to oncologists, neurosurgeons, and endocrinologists by assisting in diagnostic workup, delivery of appropriate treatment, and management of the serious metabolic and endocrine consequences.

Brain Tumors E-Book

Brain Tumors E-Book PDF Author: Andrew H. Kaye
Publisher: Elsevier Health Sciences
ISBN: 0702048186
Category : Medical
Languages : en
Pages : 931

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Book Description
Meet the increasing need for effective brain tumor management with the highly anticipated revision of Brain Tumors by Drs. Andrew H. Kaye and Edward R. Laws. Over the past decade, enormous advances have been made in both the diagnosis and the surgical and radiotherapeutic management of brain tumors. This new edition guides you through the latest developments in the field, including hot topics like malignant gliomas, functional brain mapping, neurogenetics and the molecular biology of brain tumors, and biologic and gene therapy. Benefit from the knowledge and experience of Drs. Andrew H. Kaye and Edward R. Laws, globally recognized experts in the field of neurosurgery, as well as many other world authorities.

Midline Skull Base Surgery

Midline Skull Base Surgery PDF Author: Paolo Cappabianca
Publisher: Springer
ISBN: 3319215337
Category : Medical
Languages : en
Pages : 373

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Book Description
This richly illustrated book offers detailed, step-by-step guidance on surgical approaches and techniques in patients with midline tumors of the skull base. Access routes are described from both endoscopic and microscopic standpoints, via different approaches, in order to provide a 360-degree overview of contemporary midline skull base surgery. For each pathology, the multiple surgical options and their specific indications are clearly presented, with inclusion of neuroradiological images, an anatomical dissection study and operative images and videos. The book is intended for surgeons who wish to acquire knowledge and experience in skull base surgery employing endoscopic endonasal and microsurgical transcranial techniques. It is exceptional in providing an integrated perspective that encompasses traditional microsurgical approaches and the most recent endoscopic ones, with definition of the indications for and limitations of both options.

Nutrition Disorders: Advances in Research and Treatment: 2011 Edition

Nutrition Disorders: Advances in Research and Treatment: 2011 Edition PDF Author:
Publisher: ScholarlyEditions
ISBN: 1464921849
Category : Medical
Languages : en
Pages : 404

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Book Description
Nutrition Disorders: Advances in Research and Treatment: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Nutrition Disorders. The editors have built Nutrition Disorders: Advances in Research and Treatment: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Nutrition Disorders in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Nutrition Disorders: Advances in Research and Treatment: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Tumors of the Central Nervous System, Volume 8

Tumors of the Central Nervous System, Volume 8 PDF Author: M.A. Hayat
Publisher: Springer Science & Business Media
ISBN: 9400742134
Category : Medical
Languages : en
Pages : 347

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Book Description
With tens of thousands of new CNS tumor cases each year in the US alone, this series of publications is a valuable aid to the diagnosis and treatment of these problematic neoplasms. Now, the eighth in the set returns to the topic of brain tumors, dealing with seven distinct types: astrocytoma, medulloblastoma, retinoblastoma, chordoma, craniopharyngioma, oligodendroglioma, and ependymoma. After updating the classification of medulloblastoma the volume provides an overview of ependymoma as well as describing the delineation of prognosis based on the genetic aberrations of the latter patients. The material offers key insights into the molecular pathways involved in tumor biology, such as the role of E-cadherin gene instability, carbonic anhydrase II, urokinase plasminogen activator, and Wnt signaling in meningioma. Contributors explain the genetic and clinical features associated with recurring meningioma, including the role played by erythropoietin receptor, and examine the way in which OTX2 transcription factor functions as an oncogene in medulloblastoma. With much more besides, including discussion of the molecular mechanisms that result in resistance to chemotherapy in medulloblastoma, this volume and its companions have a positive role to play in inspiring a new generation of researchers to design new drugs that are better targeted—and thus more effective.

Textbook of Uncommon Cancer

Textbook of Uncommon Cancer PDF Author: Derek Raghavan
Publisher: John Wiley & Sons
ISBN: 1119196213
Category : Medical
Languages : en
Pages : 1296

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Book Description
The fifth edition of the only comprehensive text dealing exclusively with rare or infrequently encountered malignancies in adults and children is an essential resource for any clinical oncologist. Encompasses all the information needed to diagnose and manage uncommon cancers, an area where advice and guidance is typically scarce Fully revised with new material and an evidence-based, teach-by-example approach Provides insight on real-world decision making in the clinical setting Edited and authored by a highly experienced and senior team of medical oncologists, radiation oncologists, and other specialists, giving a balanced and complete overview Extensively illustrated in full color throughout, including heat maps to show gene expression