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New Enzymes for Organic Synthesis

New Enzymes for Organic Synthesis PDF Author: Thomas Scheper
Publisher: Springer Science & Business Media
ISBN: 9783540655497
Category : Science
Languages : en
Pages : 230

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Book Description
Isolated enzymes are known as useful for synthesising of complex molecules with more and more large scale applications in recent years. These six reviews show different steps in the development of enzymatic syntheses for useful compounds. Screening of novel enzymes, their biochemical characterisation as well as reaction engineering approaches in order to increase their performance are treated in three papers. Then the use of protein design as a tool for the directed improvement of reactivity and selectivity of biocatalysts is described in two reviews. The supply of sufficient quantities of biocatalysts must not be neglected: fluidized bed adsorption as an emerging technology for the simple and fast purification of biomolecules is presented in the light of its potential in large scale supply of enzyme catalysts.

New Enzymes for Organic Synthesis

New Enzymes for Organic Synthesis PDF Author: Thomas Scheper
Publisher: Springer Science & Business Media
ISBN: 9783540655497
Category : Science
Languages : en
Pages : 230

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Book Description
Isolated enzymes are known as useful for synthesising of complex molecules with more and more large scale applications in recent years. These six reviews show different steps in the development of enzymatic syntheses for useful compounds. Screening of novel enzymes, their biochemical characterisation as well as reaction engineering approaches in order to increase their performance are treated in three papers. Then the use of protein design as a tool for the directed improvement of reactivity and selectivity of biocatalysts is described in two reviews. The supply of sufficient quantities of biocatalysts must not be neglected: fluidized bed adsorption as an emerging technology for the simple and fast purification of biomolecules is presented in the light of its potential in large scale supply of enzyme catalysts.

New Enzymes for Organic Synthesis

New Enzymes for Organic Synthesis PDF Author: Thomas Scheper
Publisher: Springer
ISBN: 9783662125922
Category :
Languages : en
Pages : 248

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Book Description
Isolated enzymes are known as useful for synthesising of complex molec ules with more and more large scale applications in recent years. Thes e six reviews show different steps in the development of enzymatic syn theses for useful compounds. Screening of novel enzymes, their biochem ical characterisation as well as reaction engineering approaches in or der to increase their performance are treated in three papers. Then th e use of protein design as a tool for the directed improvement of reac tivity and selectivity of biocatalysts is described in two reviews. Th e supply of sufficient quantities of biocatalysts must not be neglecte d: fluidized bed adsorption as an emerging technology for the simple a nd fast purification of biomolecules is presented in the light of its potential in large scale supply of enzyme catalysts.

Enzymes in Organic Synthesis

Enzymes in Organic Synthesis PDF Author: Ruth Porter
Publisher: John Wiley & Sons
ISBN: 0470718625
Category : Science
Languages : en
Pages : 192

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Book Description
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

Enzyme Catalysis in Organic Synthesis

Enzyme Catalysis in Organic Synthesis PDF Author: Karlheinz Drauz
Publisher: John Wiley & Sons
ISBN: 3527325476
Category : Catalysis
Languages : en
Pages : 1985

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Enzymes in Synthetic Organic Chemistry

Enzymes in Synthetic Organic Chemistry PDF Author: Wong
Publisher: Elsevier
ISBN: 0080505821
Category : Science
Languages : en
Pages : 389

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Book Description
This book covers the most recent development of enzymatic organic synthesis, with particular focus on the use of isolated enzymes. It is organized into one introductory chapter dealing with the characteristics of enzymes as catalysts, and five chapters dealing with different types of chemical transformations. Methods for enzyme immobilization and stabilizaton, the use of enzymes in extreme environments, and the alteration of enzyme properties by chemical modification and site-directed mutagenesis for synthetic purposes are covered.

Asymmetric Organic Synthesis with Enzymes

Asymmetric Organic Synthesis with Enzymes PDF Author: Vicente Gotor
Publisher: John Wiley & Sons
ISBN: 9783527318254
Category : Science
Languages : en
Pages : 340

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Book Description
Perfect for biochemists, synthetic and organic chemists, this book covers all important reactions, including C-C coupling reactions, oxidation reactions and many more. Divided into two parts, the first section on methodology presents new innovative methods for enzymatic catalysis optimization, including such new trends as medium engineering, directed evolution and computer-aided prediction of enantioselectivity. The second and main section deals with applications to synthesis, showing important reaction types and their applications. Only those reactions with very high selectivity are presented, allowing readers to improve their own reaction yields.

Enzymes as Catalysts in Organic Synthesis

Enzymes as Catalysts in Organic Synthesis PDF Author: Manfred P. Schneider
Publisher: Springer Science & Business Media
ISBN: 9400946864
Category : Science
Languages : en
Pages : 422

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Book Description
Proceedings of the NATO Advanced Research Workshop, Reisensburg/Ulm, Donau, Germany, June 16-22, 1985

Enzyme-Based Organic Synthesis

Enzyme-Based Organic Synthesis PDF Author: Cheanyeh Cheng
Publisher: Wiley
ISBN: 9781118027943
Category : Science
Languages : en
Pages : 544

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Book Description
Enzyme-Based Organic Synthesis An insightful exploration of an increasingly popular technique in organic chemistry In Enzyme-Based Organic Synthesis, expert chemist Dr. Cheanyeh Cheng delivers a comprehensive discussion of the principles, methods, and applications of enzymatic and microbial processes for organic synthesis. The book thoroughly explores this growing area of green synthetic organic chemistry, both in the context of academic research and industrial practice. The distinguished author provides a single point of access for enzymatic methods applicable to organic synthesis and focuses on enzyme catalyzed organic synthesis with six different classes of enzyme. This book serves as a link between enzymology and biocatalysis and serves as an invaluable reference for the growing number of organic chemists using biocatalysis. Enzyme-Based Organic Synthesis provides readers with multiple examples of practical applications of the main enzyme classes relevant to the pharmaceutical, medical, food, cosmetics, fragrance, and health care industries. Readers will also find: A thorough introduction to foundational topics, including the discovery and nature of enzymes, enzyme structure, catalytic function, molecular recognition, enzyme specificity, and enzyme classes Practical discussions of organic synthesis with oxidoreductases, including oxidation reactions and reduction reactions Comprehensive explorations of organic synthesis with transferases, including transamination with aminotransferases and phosphorylation with kinases In-depth examinations of organic synthesis with hydrolases, including the hydrolysis of the ester bond Perfect for organic synthetic chemists, chemical and biochemical engineers, biotechnologists, process chemists, and enzymologists, Enzyme-Based Organic Synthesis is also an indispensable resource for practitioners in the pharmaceutical, food, cosmetics, and fragrance industries that regularly apply this type of synthesis.

Enzymatic Reactions in Organic Media

Enzymatic Reactions in Organic Media PDF Author: A. Koskinen
Publisher: Springer Science & Business Media
ISBN: 9401106118
Category : Science
Languages : en
Pages : 314

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Book Description
The outlook of organic synthesis has changed many times during its tractable history. The initial focus on the synthesis of substances typical of living matter, exemplified by the first examples of organic chemistry through the synthesis of urea from inorganic substances by Liebig, was accepted as the birth of organic chemistry, and thus also of organic synthesis. Although the early developments in organic synthesis closely followed the pursuit of molecules typical in nature, towards the end of the 19th century, societal pressures placed higher demands on chemical methods appropriate for the emerging age of industrialization. This led to vast amounts of information being generated through the discovery of synthetic reactions, spectroscopic techniques and reaction mechanisms. The basic organic functional group transformations were discovered and improved during the early part of this century. Reaction mechanisms were elucidated at a growing pace, and extremely powerful spectroscopic tools, such as infrared, nuclear magnetic resonance and mass spectrometry were introduced as everyday tools for a practising organic chemist. By the 1950s, many practitioners were ready to agree that almost every molecule could be syn thesized. Some difficult stereochemical problems were exceptions; for example Woodward concluded that erythromycin was a "hopelessly complex target". This frustration led to a hectic phase of development of new and increasingly more ingenious protecting group strategies and functional group transformations, and also saw the emergence of asymmetric synthesis.

Hydrolases in Organic Synthesis

Hydrolases in Organic Synthesis PDF Author: Uwe Theo Bornscheuer
Publisher: John Wiley & Sons
ISBN: 3527607129
Category : Science
Languages : en
Pages : 368

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Book Description
From reviews to the first edtion: "Bornscheuer and Kazlauskas have set out, and succeeded, in producing a definitive manual on hydrolytic enzymes (especially lipases, esterases, and proteases) for organic chemists. This is quite simply the best book of its type and can be unreservedly recommended to organic chemists who have an interest in using hydrolytic enzymes in synthesis." (Nicholas J. Turner, University of Edinburgh) "The book is an indispensable source of information on the use of hydrolases in organic synthesis. The subject matter is very well set out, and the chapters are clearly written and presented from a critical viewpoint. Bornscheuer and Kazlauskas have succeeded admirably in describing the capabilities and limitations of the use of hydrolytic enzymes and in critically evaluating them. No library should be without the book." (Fritz Theil, WITEGA Angewandte Werkstoff-Forschung GmbH, Berlin) The second edition of this extremely successful and well-proven book presents recent developments in the use of hydrolases for organic synthesis, reflecting in particular the enormous progress made in enzyme discovery and optimization with a new chapter on "Protein Sources and Optimization of Biocatalyst Performance". The renowned authors survey the stereoselective reactions of hydrolases, especially lipases, esterases and proteases, giving researchers an overview of what has worked in the past so that they can judge how to solve their own synthetic problems. In total, the book contains over one thousand chemical structures, rounded off by some 1,800 invaluable references.