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Greene's Protective Groups in Organic Synthesis

Greene's Protective Groups in Organic Synthesis PDF Author: Peter G. M. Wuts
Publisher: John Wiley & Sons
ISBN: 047005347X
Category : Science
Languages : en
Pages : 1264

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Book Description

Greene's Protective Groups in Organic Synthesis

Greene's Protective Groups in Organic Synthesis PDF Author: Peter G. M. Wuts
Publisher: John Wiley & Sons
ISBN: 047005347X
Category : Science
Languages : en
Pages : 1264

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Book Description


Protective Groups in Organic Chemistry

Protective Groups in Organic Chemistry PDF Author: J. McOmie
Publisher: Springer Science & Business Media
ISBN: 1468472186
Category : Science
Languages : en
Pages : 418

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Book Description
During the past decade there has been a great increase in the use of protective groups, especially in the synthesis of large and complex organic molecules. Perhaps the greatest activity has been in the peptide field where such triumphs as the total synthesis of insulin and of bovine ribonuclease (molecular weight 13,700) have been achieved. Correspondingly, more protective groups have been devised for the protection of amino and imino groups than for any other functional group. There are many reviews and books on the synthesis of pep tides but there has been no general survey of protective groups since my 1 own review in 1963. At that time the five main methods for the removal of protective groups involved acid or base hydroly sis, reduction, oxidation, or thermal elimination reactions. Recent advances include the use of photo-sensitive and metal ion sensitive protective groups, and the attachment of functional groups to reactive polymers as a method of protec tion during the solid-phase synthesis of peptides and poly nucleotides. Another interesting development is the design and use of protective groups with a built-in 'safety-catch', which can be 'released' by a specific chemical reaction, so that an otherwise stable bond is made labile at the appropriate moment thereby allowing the protective group to be removed under very 2 mild conditions. My own interest in protective groups dates from 1944 when, as a student, I gave two lectures on the subject and produced an 11 page review including 70 references.

Protecting Groups

Protecting Groups PDF Author: Philip J. Kocienski
Publisher: Thieme
ISBN: 9781588903761
Category : Medical
Languages : en
Pages : 679

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Book Description
The didactic presentation of the material makes this book an essential bench-top tool not only for specialists in organic chemistry, but also for students and all those involved in the preparation of organic molecules. Key Features: A critical survey of the most used protecting groups, as used by organic chemists Organization based on functional groups: hydroxyl ; diol; carbonyl; carboxyl; amine Special emphasis placed on deprotection conditions applied to complex structures where selectivity is a prime issue Transformations accompanied by key experimental details Examples from the recent literature span a wide domain of organic synthesis Over 500 schemes aid visual retrieval End-of-chapter list reviews which amplify topics covered.

Greene's Protective Groups in Organic Synthesis

Greene's Protective Groups in Organic Synthesis PDF Author: Peter G. M. Wuts
Publisher: John Wiley & Sons
ISBN: 1118589327
Category : Science
Languages : en
Pages :

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Protecting Groups, 3rd Edition 2005

Protecting Groups, 3rd Edition 2005 PDF Author: P. J. Kocienski
Publisher: Georg Thieme Verlag
ISBN: 3131793937
Category : Science
Languages : en
Pages : 668

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Book Description
Protecting Groups provides a critical survey of protecting group methodology and focuses on the most widely used protecting groups for the most common functional groups. Therefore it serves as an essential learning tool for advanced students and professionals in a broad range of disciplines involving organic synthesis. The book is organized by functional group and places special emphasis on deprotection conditions applied to complex structures where selectivity is a key issue. The discussion of each protecting group is divided into three sections beginning with deprotection conditions, followed by methods of formation, and ending with some characteristic NMR data to aid the reader in identifying the contribution from the protecting group. At the end of each chapter is a list of reviews for the topics covered in that chapter. // The content of this e-book was originally published in 2007.

Protecting-Group-Free Organic Synthesis

Protecting-Group-Free Organic Synthesis PDF Author: Rodney A. Fernandes
Publisher: John Wiley & Sons
ISBN: 1119295203
Category : Science
Languages : en
Pages : 288

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Book Description
Presents a comprehensive account of established protecting-group-free synthetic routes to molecules of medium to high complexity This book supports synthetic chemists in the design of strategies, which avoid or minimize the use of protecting groups so as to come closer to achieving an “ideal synthesis” and back the global need of practicing green chemistry. The only resource of its kind to focus entirely on protecting-group-free synthesis, it is edited by a leading practitioner in the field, and features enlightening contributions by top experts and researchers from across the globe. The introductory chapter includes a concise review of historical developments, and discusses the concepts, need for, and future prospects of protecting-group-free synthesis. Following this, the book presents information on protecting-group-free synthesis of complex natural products and analogues, heterocycles, drugs, and related pharmaceuticals. Later chapters discuss practicing protecting-group-free synthesis using carbohydrates and of glycosyl derivatives, glycol-polymers and glyco-conjugates. The book concludes with a chapter on latent functionality as a tactic toward formal protecting-group-free synthesis. A comprehensive account of established protecting-group-free (PGF) synthetic routes to molecules of medium to high complexity Benefits total synthesis, methodology development and drug synthesis researchers Supports synthetic chemists in the design of strategies, which avoid or minimize the use of protecting groups so as to come closer to achieving an “ideal synthesis” and support the global need of practicing green chemistry Covers a topic that is gaining importance because it renders syntheses more economical Protecting-Group-Free Organic Synthesis: Improving Economy and Efficiency is an important book for academic researchers in synthetic organic chemistry, green chemistry, medicinal and pharmaceutical chemistry, biochemistry, and drug discovery.

Protecting Groups in Organic Synthesis

Protecting Groups in Organic Synthesis PDF Author: James Ralph Hanson
Publisher: Blackwell Science Incorporated
ISBN: 9780632045068
Category : Science
Languages : en
Pages : 130

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Protective Groups in Organic Chemistry, Edited by J.F.W. Mcomie

Protective Groups in Organic Chemistry, Edited by J.F.W. Mcomie PDF Author: John Frederick William Mcomie (Ed)
Publisher:
ISBN:
Category : Organic compounds
Languages : en
Pages : 418

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Book Description


The Organic Chemistry of Sugars

The Organic Chemistry of Sugars PDF Author: Daniel E. Levy
Publisher: CRC Press
ISBN: 1420027956
Category : Medical
Languages : en
Pages : 904

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Book Description
Intrigued as much by its complex nature as by its outsider status in traditional organic chemistry, the editors of The Organic Chemistry of Sugars compile a groundbreaking resource in carbohydrate chemistry that illustrates the ease at which sugars can be manipulated in a variety of organic reactions. Each chapter contains numerous examples demonst

Protecting Group Chemistry

Protecting Group Chemistry PDF Author: Jeremy Robertson
Publisher:
ISBN: 9780191848667
Category : Organic compounds
Languages : en
Pages : 97

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Book Description
'Protecting Group Chemistry' provides an overview of methods that allow specific sites within an organic molecule to be manipulated without affecting other sites. The author emphasises the link between the mechanisms of organic chemistry and the choice of specific protecting groups that block chemical reactivity at those sites that must remain unaffected.